Fentanyl 400 mcg

Fentanyl 400 mcg or FENTORA (fentanyl buccal tablet) is a potent opioid analgesic, intended for buccal mucosal administration. ACTIQ is available in 200 mcg, 400 mcg, 600 mcg, 800 mcg, 1200 mcg and 1600 mcg. Titrate using multiples of the 200 mcg FENTORA tablet for doses above 400 mcg (600 mcg and 800 mcg). Note: Do not use more than 4 tablets simultaneously.

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FENTORA employs the OraVescent® drug delivery technology, which generates a reaction that releases carbon dioxide when the tablet comes in contact with saliva. It is believed that transient pH changes accompanying the reaction may optimize dissolution (at a lower pH) and membrane permeation (at a higher pH) of fentanyl through the buccal mucosa.

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Active Ingredient: Fentanyl citrate, USP is N-(1-Phenethyl-4piperidyl) propionamide citrate (1:1). Fentanyl is a highly lipophilic compound (octanol-water partition coefficient at pH 7.4 is 816:1) that is freely soluble in organic solvents and sparingly soluble in water (1:40). The molecular weight of the free base is 336.5 (the citrate salt is 528.6). The pKa of the tertiary nitrogens are 7.3 and 8.4. The compound has the following structural formula:

There may be other prescriptions in the same class (that work in the same way) that could treat your condition just as well at a much lower cost. If you’re taking an expensive brand-name-only drug, it may be worth asking your doctor if there are any other less expensive, generic, or over-the-counter options that might work for you.